Oligonucleotide Principal Scientist/Director

Company: Leal Therapeutics
Location: Worcester
Posted on: May 12, 2022

Job Description:

About Leal Therapeutics:

CNS-focused biotech start-up working to develop a pipeline of novel, ultra-precise therapeutics for major CNS indications with urgent unmet needs, including neurodegeneration
Combination of internal and external programs, ranging from early preclinical to late stage clinical
Focus on technology development to improve CNS therapies
Focus on the development of truly meaningful and transformative treatments for patients with major CNS diseases and critical unmet needs
Fast-paced startup environment with broad exposure to multiple facets of biotechnology and drug development
Emphasis on cross-functional collaboration with a relatively flat and integrated structure
Continuous career development opportunities and support
Flexible schedule and location to develop a larger range of expertise and talent
Ability to have a large impact in a growing company

Leal Tx is seeking a highly driven Principal Scientist/Director to join its CMC and Platform chemistry team in Worcester, MA. The position will be responsible for leading a group of chemists in the synthesis, purification, analysis and characterization of oligonucleotides. This position will also support CMC activities in multiple programs (with internal process development and external collaborations with CMOs) and internal platform chemistry R&D projects. Experience with synthetic processes for the manufacture of nucleic acids is required.

Key Responsibilities:
- - -Review scientific journals and patents and use that information to formulate a chemical synthesis route for chemical platform development
- - -Lead a group of chemists in the synthesis, purification, conjugation, isolation and related processing activities of oligonucleotides to support chemical platform.
- - -Develop new chemical entities to support delivery of oligonucleotides.
- - -Develop methods for the analytical characterization of oligonucleotides
- - -Work independently to solve non-routine chemical synthesis problems, especially in the area of nucleoside and nucleotide chemistry
- - -Document all work in laboratory notebook or batch records as applicable
- - -Adhere to all company environmental, health and safety policies
- - -Demonstrated proficiency in preparation of technical presentations, reports and publications in English

Job Knowledge Required:
- - -PhD in Chemistry or equivalent with years of experience
- - -5 or more years of direct experience in oligonucleotide chemistry required
- - -Strong organizational and communication skills required
- - -Ability to work collaboratively in a fast-paced, dynamic environment required
- - -Track record of solving non-routine chemistry problems
- - -Operation, maintenance, and troubleshooting of lab equipment including synthesizers, purifiers, UF/DF systems, UV Specs, UPLC and Mass Spectrometers.

If interested, please contact Human Resources (humanresources@lealtx.com) or Eduardo Paredes (eduardo.paredes@lealtx.com) with a brief statement of interest and resume.

Keywords: Leal Therapeutics, Worcester , Oligonucleotide Principal Scientist/Director, Executive , Worcester, Massachusetts