Oligonucleotide Principal Scientist/Director
Company: Leal Therapeutics
Location: Worcester
Posted on: May 12, 2022
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Job Description:
About Leal Therapeutics:
CNS-focused biotech start-up working to develop a pipeline of
novel, ultra-precise therapeutics for major CNS indications with
urgent unmet needs, including neurodegeneration
Combination of internal and external programs, ranging from early
preclinical to late stage clinical
Focus on technology development to improve CNS therapies
Focus on the development of truly meaningful and transformative
treatments for patients with major CNS diseases and critical unmet
needs
Fast-paced startup environment with broad exposure to multiple
facets of biotechnology and drug development
Emphasis on cross-functional collaboration with a relatively flat
and integrated structure
Continuous career development opportunities and support
Flexible schedule and location to develop a larger range of
expertise and talent
Ability to have a large impact in a growing company
Leal Tx is seeking a highly driven Principal Scientist/Director to
join its CMC and Platform chemistry team in Worcester, MA. The
position will be responsible for leading a group of chemists in the
synthesis, purification, analysis and characterization of
oligonucleotides. This position will also support CMC activities in
multiple programs (with internal process development and external
collaborations with CMOs) and internal platform chemistry R&D
projects. Experience with synthetic processes for the manufacture
of nucleic acids is required.
Key Responsibilities:
- - -Review scientific journals and patents and use that
information to formulate a chemical synthesis route for chemical
platform development
- - -Lead a group of chemists in the synthesis, purification,
conjugation, isolation and related processing activities of
oligonucleotides to support chemical platform.
- - -Develop new chemical entities to support delivery of
oligonucleotides.
- - -Develop methods for the analytical characterization of
oligonucleotides
- - -Work independently to solve non-routine chemical synthesis
problems, especially in the area of nucleoside and nucleotide
chemistry
- - -Document all work in laboratory notebook or batch records as
applicable
- - -Adhere to all company environmental, health and safety
policies
- - -Demonstrated proficiency in preparation of technical
presentations, reports and publications in English
Job Knowledge Required:
- - -PhD in Chemistry or equivalent with years of experience
- - -5 or more years of direct experience in oligonucleotide
chemistry required
- - -Strong organizational and communication skills required
- - -Ability to work collaboratively in a fast-paced, dynamic
environment required
- - -Track record of solving non-routine chemistry problems
- - -Operation, maintenance, and troubleshooting of lab equipment
including synthesizers, purifiers, UF/DF systems, UV Specs, UPLC
and Mass Spectrometers.
If interested, please contact Human Resources
(humanresources@lealtx.com) or Eduardo Paredes
(eduardo.paredes@lealtx.com) with a brief statement of interest and
resume.
Keywords: Leal Therapeutics, Worcester , Oligonucleotide Principal Scientist/Director, Executive , Worcester, Massachusetts
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