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Scientist I/II, Immunology Discovery, Fibroblast iADC

Company: AbbVie
Location: Worcester
Posted on: January 16, 2020

Job Description:

Our Abbvie Immunology team investigates novel solutions to help improve patient care across a variety of autoimmune and chronic infectious diseases with unmet needs. We focus our target discovery efforts on pathways that have direct correlates with disease activity and patient symptoms. We are seeking a passionate and hardworking scientist to join our team in Worcester, MA. Our team offers an outstanding opportunity to work in a dynamic, innovative, and multi-disciplinary environment to develop your career at the interface of basic research, target discovery and early drug discovery. As a key member of our team, you will be responsible for the design, execution, and analysis of immune cell-based assays. You will work independently, have excellent technical, written and oral communication skills and be a part of a team matrix environment. Key Responsibilities Include:

  • Tissue handling and processing for molecular and cellular phenotyping and functional cellular assay experiments
  • Design, develop, evaluate and implement well-controlled in vitro assays to address target biology and drug biology
  • Planning and coordination of experiments with team members and facility operations.
  • Analysis and presentation of data, providing scientific interpretations and recommendations in lab meetings and project team meetings
  • Maintaining accurate and well-organized records and laboratory notebook
  • Supporting the development of protocols, study reports and data presentations Position will be hired based on level of experience.
    • Bachelors or Masters in Immunology or closely related field with typically 5-7+ (BS), or 2-5+ (MS) years of experience
    • A strong research background in molecular and cellular immunology, specifically with working knowledge in fibroblast biology is highly preferred
    • General understanding of molecular and transcriptional pathways regulating fibroblast proliferation, differentiation, and activation
    • Proficient in multi-color flow cytometry - both handling flow cytometer (Fortessa, Canto LSR) and independently analyze the data using analytical software such as FlowJo is required
    • Extensive tissue culture experience and manipulation of primary cells from mouse or human tissue
    • Experience with culturing and manipulating fibroblast cells
    • Knowledge of in vivo model systems for fibrosis and RA would be a plus
    • Basic immunological and molecular biology assay skills: Tissue culture, Transfection, ELISA, Western blot, intracellular cytokine analysis, Luciferase assay Key AbbVie Competencies:
      • Builds strong relationships with peers and cross-functionally with partners outside of the team to enable high performance
      • Learns fast, grasps the "essence" and can change the course quickly where indicated
      • Raises the bar and is never satisfied with the status quo
      • Creates a learning environment, is open to suggestions and experimentation for improvement
      • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Keywords: AbbVie, Worcester , Scientist I/II, Immunology Discovery, Fibroblast iADC, Healthcare , Worcester, Massachusetts

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