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Senior Scientist II/ Principal Research Scientist I, New Biological En

Company: AbbVie
Location: Worcester
Posted on: February 14, 2020

Job Description:

AbbVie Analytical Research & Development (Analytical R&D) is a global analytical sciences organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative small molecule and therapeutic biologic medicines and spans from the selection of Discovery candidate molecules through the transition of analytical methods and testing to commercial labs to support product launch. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make substantial contributions to advance AbbVie's pipeline of innovative medicines! Careers in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies. We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.Key Responsibilities Include:

  • Characterization of monoclonal antibodies, antibody-drug-conjugates, novel multi-specifics and fusion proteins.
  • Employ modern LC-MS instruments to understand structural information insight of therapeutic biologic molecules and assess their quality.
  • Compilation and assessment of analytical data (e.g. mass spec) regarding function and stability of the molecule to support candidate screening in high throughput.
  • Elucidation of structure and impurity/variant characterization of antibody-based drug materials.
  • Build and lead strategic alignments with key partners, revise and improve business workflows, run project timelines and resources.
  • Develops the efficient CMC development path for assigned discovery projects together with clients from various discovery and development functions with an emphasis on collaboration, quality and with a sense of urgency.
  • Operates in a matrix team environment, aligning across and executing shared departmental and divisional strategies.
  • Data review, documentation and preparation of technical memos and reports.
  • Mentor junior staff on troubleshooting equipment and experimental problems
  • Provision of scientific expertise and engagement in cross-functional teams within AbbVie.
  • Takes initiative to develop independent research ideas and pursues scientific questions that may arise during candidate selection/ nomination screening studies.
  • Presents data at internal and external professional conferences and prepares manuscripts for publication in peer reviewed journals or patent applications. Position will be hired based on level of experience.
    • Bachelors, Masters or PhD degree in Chemistry, Biochemistry, or Chemical Engineering with typically 10-12+(BS), 8-10+ (MS) or 4-6+ (PhD) years of experience.
    • Effective writer and communicator of research or other regulatory materials.
    • At least 2 years of hand-on experience in comprehensive characterization of monoclonal antibodies in an industry setting is preferred.
    • Deep understanding of protein characterization by LC/ESI-HR-MS (e.g. peptide Mapping, intact mass analysis) and insights into the causes for protein aggregation
    • Knowledge of functional excipient degradation pathways is a plus
    • Profound expertise in determination of PTM and chemical modifications and their influence on the molecule's function and structure
    • Robotics expertise and protein analytical experience (e.g. SEC, IEX, HIC, CE) is preferred
    • Highly motivated, ambitious and results-oriented person with excellent communication and presentation skills
    • High degree of flexibility in adapting to different projects and people; embraces the ideas of others, cultivates innovation and leads innovation to reality
    • Excellent teammate with the ability to build networks with Peers
    • Fluency in English is required Key AbbVie Competencies:
      • Builds strong relationships with peers and cross functionally with partners outside of teams to enable higher performance.
      • Learns fast, grasps the "essence" and can change course quickly where indicated.
      • Raises the bar and is never satisfied with the status quo.
      • Creates a learning environment, open to suggestions and experimentation for improvement.
      • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Keywords: AbbVie, Worcester , Senior Scientist II/ Principal Research Scientist I, New Biological En, Other , Worcester, Massachusetts

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