Research Associate I
Company: University of Massachusetts Medical School
Posted on: June 12, 2021
GENERAL SUMMARY OF POSITION:
Dr. Yingleong (Rigel) Chan's laboratory seeks a highly motivated
individual with substantial biological mammalian cell culture
expertise to perform in-vitro experimentation with human cells. The
applicant will be responsible for a wide array of biological
assays, including the generation and culture of human-induced
pluripotent stem cells (iPSCs), differentiating them into various
adult tissue types (microglia, astrocytes, neural progenitors,
cerebral organoids, etc.) and performing in-vitro phenotypic assays
on them, including viral infection as well as determining various
immune phenotypes. Other phenotypes also include cell-death due to
exposure to certain drugs or chemicals. Phenotyping is performed
mainly using flow cytometry as well as cell sorting using FACS.
Depending on the level of expertise and the research interest of
the individual, the position allows for developing computational
and statistical methods in the context of ongoing projects.
Under the direction of the Principal Investigator or designee,
the Research Associate I performs a variety of complex research
- Perform complex laboratory experiments
- Conduct in-depth analysis of research experiments
- Interpret data, form conclusions, and decide on and plan the
next experiments to be done with a high degree of independence
- Write standard operating procedures, schedule work, analyze
data, maintain accurate records, and write reports
- Compile and analyze data. Perform computations using image
analysis software, spreadsheets, graphing, and curve fitting
- May modify protocols and be responsible for a single,
independent research project
- May assist with budget and/or operational aspects of grant and
- Assist in writing the text of scientific publications and
grants. Review literature
- Train new laboratory personnel, students, and
- Comply with all safety and infection control standards
- Perform other duties as required.
- Bachelor's degree in the Biological Sciences, or equivalent
- 3 years of relevant research experience
- Knowledge of Microsoft Office products
- Strong ability to analyze complex visual data in a quantitative
and objective manner
- Judgment and action skills required to solve commonly
- Experience in human cell line culture including culture of
induced pluripotent stem cells (iPSCs).
- Experience in iPSCs to adult tissue type differentiation.
- Experience in viral infection of human cells.
- Experience in cell staining and flow cytometry assays.
- Experience in performing experiments required for
next-generation sequencing. Genomic DNA extraction, DNA library
Under the direction of the Principal Investigator, or
May functionally supervise aides, technicians, and
ENVIRONMENTAL WORKING CONDITIONS:
Wet chemistry laboratory, and may require appropriate contact
with biohazards, radionuclides, toxins, animals, and human
Keywords: University of Massachusetts Medical School, Worcester , Research Associate I, Other , Worcester, Massachusetts
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