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Scientist I/II, Assay Development

Company: AbbVie
Location: Worcester
Posted on: September 23, 2022

Job Description:

Purpose:


  • Generate cell lines and conduct assays for screening candidate antibodies and other recombinant biologics from pipeline projects across different therapeutic areas.
  • Design, execute and optimize functional assays for characterizing antibodies using robotic liquid handlers.

    Responsibilities:

    • Develop, characterize, and optimize transient and stable cell lines that are used in luminescence and fluorescence based reporter assays, for screening antibodies and other recombinant biologics.
    • Design, optimize, and execute binding assays (e.g. ELISA, flow cytometry) and functional assays (e.g. luminescent and fluorescent reporter cell assays, adhesion, aggregation, phagocytosis, internalization, live-cell imaging etc) for antibody screening and characterization. -
    • Carry out high-throughput screening (HTS) assays using robotic liquid handlers.
    • Collaborate efficiently across different functional groups to achieve goals within project timelines.
    • Analyze data, prepare reports and technical presentations to communicate progress to project teams.

      Qualifications: -

      • BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
      • Expertise in transient and stable cell line generation through chemical transfection, electroporation and lentiviral transduction methods is required.
      • Expertise in conducting and optimizing assays for antibody characterization and functional screening using FACS, ELISA, luminescence/fluorescent cell-based assays, and live cell imaging is required.
      • Demonstrate ability to independently design, execute and interpret experiments, and master new experimental techniques
      • Demonstrate strong communication and collaboration skills and ability to multi-task and work within timelines

Keywords: AbbVie, Worcester , Scientist I/II, Assay Development, Other , Worcester, Massachusetts

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