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Scientist I/II, Conjugation Chemist

Company: AbbVie
Location: Worcester
Posted on: April 16, 2019

Job Description:

AbbVie Bioresearch Center in Worcester, MA has an opening for a Scientist I/II in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs). Key Responsibilities Include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.
  • Optimization and validation of conjugation protocols and formulation buffers.
  • Optimization of automated techniques for ADC synthesis and purification. Position will be hired based on level of experience.
    • BS or MS degree with 5-8+ (BS) or 2-5+ (MS) years of experience in Analytical Chemistry, Biochemistry, Chemistry or other relevant discipline.
    • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.
    • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired.
    • Hand on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
    • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Keywords: AbbVie, Worcester , Scientist I/II, Conjugation Chemist, Other , Worcester, Massachusetts

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