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Scientist II/ Senior Scientist I, Purification, Process Sciences

Company: AbbVie
Location: Worcester
Posted on: October 12, 2019

Job Description:

A Scientist position is available within our Purification group in the Process Sciences Department at the AbbVie Bioresearch Center in Worcester, MA. We are responsible for developing and supporting downstream manufacturing process for early and late phase clinical biologics programs. We strive for speedy delivery of high quality processes that are high yield with desirable product qualities, cost-effective, manufacturing friendly, and robustness. We interact closely with Discovery, Cell Culture Development, Pilot Lab, Protein Analytics, Drug Product Formulation Development, Manufacturing, Quality, and CMC teams. We are seeking a hardworking, creative scientist who will make tangible contribution to the continuous improvement and innovation within the organization in delivering innovation therapies to the patients. Key Responsibilities Include:

  • Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for recombinant proteins
  • Design and execute creative process development and characterization activities, impurity and viral clearance studies
  • Responsible for technology transfer to scale-up labs and manufacturing facilities, troubleshooting and investigation activities
  • Address and tackle technical problems independently, conceive and implement creative process research ideas, evaluate and integrate state-of-the-art technology to improve manufacturing platform, pursue deep understanding of the process and product, and demonstrate a high level of scientific initiative
  • Author technical report, support and contribute to regulatory filings
  • Provide project update and analysis to multi-functional team and management
  • Present creative work internally across departments and at external conferences
  • May author or co-author peer-reviewed scientific papers or patents Position will be hired based on level of experience.
    • Bachelors, Masters, or PhD degree in Chemical Engineering or Biochemical Engineering or related disciplines with typically 7-10+ (BS), 5-8+ (MS), or 0+ (PhD) years of experiences in protein purification process development and/or manufacturing support; Pharmaceutical industry experience preferred
    • Sound scientific understanding of current protein separation technologies and ability to explore and develop new approaches to further advance creative purification technologies desirable
    • Expertise in protein chromatography, membrane filtration, mechanistic and process modeling, a plus
    • Basic knowledge in related functional areas, such as cell culture, protein chemistry and analytics or formulation is desirable
    • Consistent record of independent thought, creativity and scientific accomplishments (e.g. peer reviewed journal publications, patents)
    • You should be a goal oriented teammate with excellent verbal and written communication skills Key Leadership Competencies:
      • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
      • Learns fast, grasps the "essence" and can change course quickly where indicated
      • Raises the bar and is never satisfied with the status quo
      • Creates a learning environment, open to suggestions and experimentation for improvement
      • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Keywords: AbbVie, Worcester , Scientist II/ Senior Scientist I, Purification, Process Sciences, Other , Worcester, Massachusetts

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