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Scientist II/ Senior Scientist I, Conjugation Chemist

Company: AbbVie
Location: Worcester
Posted on: November 11, 2019

Job Description:

Our Global Biologics Antibody Drug Conjugates (ADC) team located at the AbbVie Bioresearch Center in Worcester, MA is looking for a Conjugation Chemist to join their team! As a key member of the team, you will be responsible conduct pre-clinical research and development in the area of ADC! Key Responsibilities: Synthesis, purification and characterization of ADCs on mg to gram scale Development and optimization of conjugation protocols utilizing novel chemistries and technologies Demonstrating automated techniques for ADC synthesis and purification Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie Position will be hired based on level of experience. Bachelors, Masters or Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology or closely related field with typically 7-10+(BS), 5-8+(MS), 0+(Ph.D) years of experience; Industry experience preferred Hands-on experience with generation and characterization of antibody drug conjugates; Preferably in the area of biotherapeutics Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography-mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF) Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography Experience with GE AKTA FPLC and unicorn software preferred This position requires an individual who is proactive, enthusiastic, hard-working, organized and able to work in a fast-paced team environment with proven problem solving skills High-quality written and oral communication skills and the ability to excel in a collaborative environment are critical Key Leadership Competencies: Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance Learns fast, grasps the "essence" and can change course quickly where indicated Raises the bar and is never satisfied with the status quo Creates a learning environment, open to suggestions and experimentation for improvement Embraces the ideas of others, nurtures innovation and manages innovation to reality

Keywords: AbbVie, Worcester , Scientist II/ Senior Scientist I, Conjugation Chemist, Other , Worcester, Massachusetts

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